Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus

Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus.

OBJECTIVE To evaluate the perinatal impact of metformin and glyburide in the treatment of gestational diabetes mellitus (GDM). METHODS A randomized clinical trial conducted from July 2008 until September 2010 studied 200 pregnant women with GDM who required adjunctive therapy to diet and physical activity. Patients were randomized to use metformin (n=104) or glyburide (n=96). The drugs were r...

Comparison of Metformin and Insulin in treatment of Gestational Diabetes Mellitus

Introduction: Gestational Diabetes Mellitus (GDM) is one of the complications of pregnancy that has some maternal and neonatal outcomes. Some drugs such as insulin and oral agents (metformin, ...) are used for management of GDM. The aim of this study was to compare metformin and insulin in treatment of GDM Methods: This clinical trial was carried out in 2009-2011. Sample size was 201 patient...

Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study.

OBJECTIVE To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS In this prospective randomized controlled study, we randomly assigned patients with GDM at 13-33 weeks gestation and whose blood glucose was poorly controlled by diet to receive either glyburide or metformin. If ...

Metformin in Gestational Diabetes Mellitus

Metformin in gestational diabetes mellitus